CrossOver is an emulation system (it's Wine-based), so you are going to get a graphical/performance hit. Depending on the game you're playing, this isn't so bad. Any games from the '90s that aren't demanding should be fine. Playing the brand new hotness will suck more, depending on your hardware. I can play Guild Wars 1 excellently on a MacBook with 2GB of RAM, I wouldn't even try to touch GW2, for example.
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