Like 709, I too have about 294 trazillion fonts. I've used FontAgent Pro exclusively for over three years now. I love it.
It's the closest thing I've seen since my beloved ATM Deluxe, which, sadly, never made the leap over to OS X.
Auto opening and closing, a clean, intuitive interface, great organization and some useful capabilities and features...and, best of all, no-brainer simplicity.
Nothing but good things to say...it's never given me a single problem.
http://www.insidersoftware.com/FA_pro_osx.php